KPV 10MG

KPV (lysine-proline-valine) is the C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (alpha-MSH), and it has been studied as the minimal sequence retaining the parent molecule's anti-inflammatory signaling properties. Research into KPV grew from the observation that alpha-MSH modulates inflammatory cascades through melanocortin receptors, and that much of this activity could be mapped to its final three residues. In preclinical models, KPV has been investigated in the context of inflammatory bowel paradigms, dermal inflammation models, and NF-kB pathway studies — a remarkably broad footprint for a tripeptide. Its small size makes it useful for structure-activity research on melanocortin signaling, and it is frequently included in peptide panels exploring the intersection of pigmentation biology and immune modulation. Laboratories value it as a precisely defined fragment for dissecting which portions of alpha-MSH drive specific downstream effects. As the minimal active fragment of alpha-MSH, it is a textbook example of pharmacophore minimization in peptide science. For laboratory research use only. Not for human or veterinary use.